Feb 2019: We published the first application of our novel, directional signaling measure to brain data from patients with Alzheimer's disease (AD). We found that specific routes of directional signaling, or effective connectivity, are disrupted in the default mode network of patients. This approach, based on simultaneous PET/MR imaging, might offer a link to molecular spreading theories of AD-pathology in the human brain.
Please find the publication in the journal Human Brain Mapping, title: Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease—A simultaneous resting‐state FDG‐PET/fMRI study by Scherr et al.